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| Possible Coronavirus Treatments through Different Medicinal Ways and Herbs. Medically Observed Best Ways to Treat Coronavirus |
Dr. John Wright, of Bradford Royal Infirmary (BRI), explains some of the ongoing trials for the treatment of COVID 19 and says that a combination of three different types of drugs could be key.
At Bradford Royal Infirmary, we are now participating in eight different trials to find a cure for code 19. We are part of a larger international effort. It is as if all the light of world science is focused on this virus, which is almost invisible like a laser beam. The recovery trial is one of the biggest trials we are currently involved in. It has already included more than 10,000 patients across the country who are either taking the placebo or taking one of the various drugs.
At BRI last week, we selected the first patient in the UK for a small trial to test whether the new drug developed by AstraZeneca was safe and effective. This is one of several small trials collectively called the Accord Trial and may include more drugs in the recovery trial.
It is hoped that this unadulterated AstraZeneca drug will help prevent immune system activity in a small group of patients from exceeding a dangerous level in which the body is in a state of trauma. It goes away and causes closure of vital organs such as the lungs, heart, blood vessels, and kidneys.
This extreme reaction is called 'cytokine storm' in medical terms. Cytokines are molecules that signal the presence of an infection so that the body's immune system can fight off it. This new drug inhibits cytokines called IL-33 (or interleukin-33).
Mark Winterbourne has volunteered to use IL Blocker. He arrived at the hospital with symptoms that were previously thought to be caused by leaf stones.
When they tested positive for Code 19, we realized that the virus was a possible source of the problem. (Code 19 is a disease that has many symptoms. But this is a rare case!) Mark says that volunteering is part of his nature. While working as a volunteer photographer for the Great North Run, she met and befriended Sir Mo Farah.
I think it could take at least a year to develop a vaccine for code 19, so these trials are very important for finding a cure.
Doctors hope that in the near future, if a person comes to the testing center with the initial symptoms, his saliva will be tested immediately and he will be able to prescribe effective medicine before the very bad symptoms appear. ۔
This combination may include an antiviral drug, an anti-immune drug, and an anti-inflammatory drug.
Some of the antiviral drugs being tested will be able to prevent the coronavirus from entering the lungs, while other types of drugs can help stop it from growing in the body.
Immune control drugs will help prevent the immune system from overreacting to the virus. If the IL-33 blocker of Accord Trials is effective, it will be able to stop the spread.
Anti-inflammatory drugs include steroids. Dexamethasone, for example, is one of the first drugs to be used in recovery trials.
It seems that a single drug will not be enough to treat code 19. Earlier, we used a combination of different drugs to fight TB. In the same way, we can defeat this disease by combining antibiotics and HIV with antiretroviral drugs.
BRI respirator Dinesh Saralia is hopeful that a mix of different medicines will be available before the end of summer.
"I think we will get at least two or three medicines that will not make these patients feel the need to come to the hospital," he said.
"You will go to the test center and then you will be given medicine once you are diagnosed with the disease. Under the current strategy, if you are found to have the cod virus, you are isolated and isolated and your condition worsens, you have a fever, you start having trouble breathing, then you go to the hospital. come. But people need to be given medicine much earlier and sooner.
Our second consultant is likely participating in another trial in which she is participating as a donor of antibodies.
Debbie Horner was diagnosed with code 19 at the onset of the epidemic and soon recovered. Two weeks ago, when people like her got a call to donate blood for the plasma, she immediately agreed.
Researchers want to know if the plasma-rich antibodies of people recovering from COD 19 can help other patients fight the disease. This work is also part of the recovery trial.
It has now been found that high levels of antibodies in the blood are more likely to occur in patients who are over 35 years of age and who have become so ill that they need hospital treatment.
The Blood and Transplant Department (NHSBT) of the National Health Service seeks to deploy donors who recover from Code 19 who are male or over 35 years of age or have become so ill that they are hospitalized. I had to enter.
Debbie's symptoms were relatively mild, so her antibody plasma may not be as effective as the research team wanted. The results have not been released yet. They are happy to donate if they need a plasma.
"It's different from a normal blood transfusion," she says. They take part in the blood plasma and then they give you back all your red blood cells and other blood components you don't need. It just feels like you're running out of water. '
Debbie says a few cups of tea is enough to fix it.
Mike Murphy, professor of transfusion medicine at Oxford University, says it's a great opportunity to learn a little more about plasma transfer in general. He says plasma was collected in the late 2000s to see if it could be a way to treat people infected with Ebola and the flu.
But by the time the large number of plasma donors who had recovered from the infection had reached the peak of the infection, there was no opportunity to try a plasma treatment. However, the epidemic of code 19 is clearly different.
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